Evidence from observational studies is accumulating, suggesting that the majority of deaths due to SARS-CoV-2 infections are statistically attributable to vitamin D insufficiency and could potentially be prevented by vitamin D supplementation.

Key Points

  • Mortality was much higher among vitamin D insucient patients than
    among other patients.
  • These results imply that 87% of COVID-19 deaths may be statistically attributed to vitamin D insuciency and could potentially be avoided by eliminating vitamin D insufficiency.
  • Besides other population-wide measures of prevention, widespread vitamin D3 supplementation at least for high-risk groups, such as older adults or people with relevant comorbidity, which has been proven by randomized controlled trials to be beneficial with respect to prevention of other acute respiratory infections and acute acerbation of asthma and chronic pulmonary disease [6–10], should be promoted.

Brenner, H.; Schöttker, B. Vitamin D Insufficiency May Account for Almost Nine of Ten COVID-19 Deaths: Time to Act. Comment on: “Vitamin D Deficiency and Outcome of COVID-19 Patients”. Nutrients 2020, 12, 2757. Nutrients 202012, 3642. https://doi.org/10.3390/nu12123642

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